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Patients receiving tirzepatide 10 mg or 15 mg achieved mean weight reductions of 9.3 kg and 11.2 kg respectively over 40 weeks, demonstrating that tirzepatide's weight loss efficacy remains substantial when added to existing metformin therapy

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The complex travels through the small intestine until it reaches the terminal ileum, where specialised receptors called cubam (a complex of cubilin and amnionless proteins) recognise and facilitate the uptake of the B12-IF complex into enterocytes (intestinal cells)